Dados do Trabalho

Título

Exogenous Melatonin: Efficacy, Safety, and Clinical Indications

Introdução

Melatonin, an endogenous neuro-hormone derived from serotonin, plays a crucial role in regulating the sleep-wake cycle and circadian rhythm. Exogenous melatonin has gained attention as a potential treatment for sleep disorders and other conditions.The rise in popularity of this substance as a treatment for sleep disorders demands further investigation into its efficacy and safety

Objetivo

This study aims to review the current scientific literature on the use of exogenous melatonin in various clinical conditions, evaluating its efficacy, safety, and recommended dosages and applications.

Métodos

A narrative literature review was conducted using the descriptor "exogenous melatonin" in the PUBMED database, with a publication date limit of 10 years. A total of 1204 articles were initially identified, with inclusion criteria focusing on human studies regarding patients with no outlining comorbidity with sample sizes of 20 participants or more. In total, 14 studies were included.

Resultados

The review synthesized data on the efficacy and safety of exogenous melatonin across the observed groups. Studies highlighted significant improvements in sleep quality, such as delayed sleep onset. Various dosages and administration protocols were explored, showing promising outcomes in sleep management.

Conclusões

Exogenous melatonin demonstrates potential benefits in improving sleep disorders, with a favorable safety profile in short-term use. However, long-term safety considerations, especially in vulnerable populations, warrant further investigation. This review provides insights for healthcare professionals and patients, emphasizing the need for evidence-based guidelines and future research directions. The study highlights the need for further research regarding dosage of exogenous melatonin on the treatment of sleep disorders.

Palavras -chave

Melatonin, Exogenous, Efficacy, Safety, Clinical Indications