Dados do Trabalho

Título

Association between changes in body composition and sleep characteristics in individuals with COPD: preliminary results

Introdução

Chronic obstructive pulmonary disease (COPD) is a multisystem condition characterized by various manifestations, including alterations in body composition and sleep disturbances. These factors alone are linked to decreased exercise capacity, quality of life and increased mortality. Nevertheless, the correlation between longitudinal changes in body composition and sleep has not been explored in this population.

Objetivo

To correlate changes in body composition with subjective and objective aspects of sleep in individuals with COPD.

Métodos

In this prospective cohort study with a 12month follow-up, individuals diagnosed with COPD underwent pulmonary function assessment through spirometry and sleep evaluation using the Pittsburgh Sleep Quality Index and the Actiwatch monitor over a period of 7 days. Body composition was evaluated using electrical bioimpedance at two different assessment points (baseline [AV1] and after 12months [AV2]), and the changes in variables were calculated as AV2-AV1. Statistical analysis was performed using the Shapiro-Wilk test and Spearman's correlation coefficient. Data were analyzed using SPSS software, and statistical significance was p<0.05.

Resultados

16 individuals with COPD were included (9men; 71±8years; BMI 24±7kg/m2; FEV1 61±16%predicted). There were significant correlations between change in fat free mass (FFM)(Kg) and total sleep time(%)(r=0.68,p=0.015), sleep efficiency(%)(r=0.69,p=0.013), duration of sleep blocks(min)(r=0.63,p=0.028) and time awake after sleep onset(WASO), both in min and %(r=-0.59,p=0.042 and r=-0.68,p=0.015, respectively). Changes in FFM (%) correlated significantly with WASO(min)(r=-0.62,p=0.033) and duration of sleep blocks(min)(r=0.63,p=0.028), whereas changes in the FFM index correlated with sleep efficiency(%)(r=0.61,p=0.036). Regarding the results of changes in fat mass (FM)(Kg), there was significant correlation with number of blocks in wakefulness and sleep (r=0.60,p=0.038 for both), whereas the change in FM(in%) correlated significantly with duration of sleep blocks(min)(r=-0.63,p=0.028) and WASO (min)(r=0.62,p=0.033). Finally, the change in FM index correlated with the number of blocks in wakefulness and sleep (r=0.60,p=0.038 for both). No significant correlations were observed with subjectively assessed sleep.

Conclusões

Changes in body composition, particularly the decrease in FFM and increase in FM, are inversely linked to different aspects of objectively assessed sleep in individuals with COPD.

Palavras -chave

COPD; Body composition; Sleep.