Dados do Trabalho

Título

INTERVENTION WITH EXOGENOUS MELATONIN IN FEMALE SHIFTWORKERS DURING CLIMACTERIC PHASE: EFFECTS ON SLEEP QUALITY ON WORKDAYS.

Introdução

Menopause is the period when menstruation permanently ceases, defined by 12 consecutive months of amenorrhea, typically occurring between the ages of 45 and 55. Climacteric encompasses perimenopause and postmenopause and is characterized by hormonal changes, such as decreased follicular activity and fertility, as well as alterations in the menstrual cycle. Many women experience symptoms of climacteric syndrome, such as hot flashes, insomnia, and irritability. Studies show that sleep disturbances increase during this transition, regardless of other factors.

Objetivo

To analyze the effects of exogenous melatonin administration on sleep quality on workdays in 46 women in the climacteric phase.

Métodos

This study, a randomized clinical trial, was conducted with 46 nursing working three shifts: (7h-13h, n=16), (13h-19h, n=15) and (19h-7h, n=15) in a hospital in São Paulo. In each shift, the volunteers were divided into intervention group and placebo group. The intervention group received 0.3mg of 6-sulfatoxymelatonin to be taken on alternate nights. The placebo group received an identical placebo capsule with the same instructions. Data collection used the Pittsburgh Sleep Quality Index (PSQI). Data analysis was performed with Stata 16 and Jamovi, including descriptive analysis, Generalized Linear Model (GLM) adjusted for race, and post hoc analysis for groups with statistical differences.

Resultados

The study volunteers had a mean age of 47.2 years and 34.7% had already gone through menopause. A significant difference in sleep quality on workdays was observed between groups (p<0.01) and in the interaction between group and menopausal status (p<0.05) before and after the intervention, regardless of the race, was found. Post hoc analysis showed a significant difference between groups (p<0.05) with a 22.1% improvement in sleep quality on workdays in the intervention group. In addition, the intervention group that went through menopause improved 29.63% their sleep quality compared to the placebo group that went through menopause (p<0.05). Finally, the intervention group that had not had menopause improved by 14.62% sleep quality to the placebo group that had menopause on workdays (p<0.05).

Conclusões

The administration of exogenous melatonin was shown to be effective in improving sleep quality on workdays in climacteric women, especially in those who had already gone through menopause, regardless of the race.

Palavras -chave

Climacteric. Melatonin. Sleep Quality.