Dados do Trabalho

Título

Insomnia and Risk of Alzheimer's Disease Development: A Systematic Review and Meta-Analysis

Introdução

Insomnia, characterized by difficulty falling asleep, has been associated with a higher risk of cognitive impairment in older adults. In this meta-analysis, it was examined whether insomnia interferes with the development of dementia.

Objetivo

To identify the relation of Alzheimer disease development and insomnia.

Métodos

We used the PRISMA checklist for this systematic review and meta-analysis. Cochrane, PubMed, and Scopus databases were searched for studies comparing the association between insomnia and Alzheimer's Disease. Odds ratio (OR) was used for binary outcomes with 95% confidence interval (CI). Statistical analysis was performed using R software 4.4.1.

Resultados

A total of five studies were included, comprising 30,472,935 patients, of whom 13,5% had insomnia. The analysis showed that insomnia was not associated with higher risk of development of Alzheimer (OR 1.39; 95% CI 0,97-2.01; p = 0.01, I²=83%). The analysis of depression and risk of Alzheimer showed significantly different distributions between groups (OR 1.70; 95% CI 1.27-2.27; p = 0.0004; I²=99%) in favor of the depression-free group.

Conclusões

In this meta-analysis of 5 studies, we can observe that there is no relation between insomnia and the risk of developing Alzheimer's disease.

Palavras -chave

Insomnia; Alzheimer's disease; Sleep disorders.