Dados do Trabalho

Título

Insomnia and Risk of Cancer: a Systematic Review and Meta-analysis

Introdução

Insomnia, marked by ongoing trouble with falling asleep or staying asleep, has been progressively associated with several health problems, including cancer. Studies suggest that long-term insomnia can interfere with the body's circadian rhythms and immune function, which might elevate the risk of developing cancer.

Objetivo

Insomnia can predict a high risk of cancer.

Métodos

Cochrane, Embase and PubMed databases were searched for studies comparing people suffering from insomnia to non-insomnia people in the context of risk of cancer. A Random-effects model was employed to compute the Hazard Ratios (HR) with 95% Confidence Intervals (CI). Statistical Analyses were performed utilizing ReviewManager (RevMan) 5.4.1.

Resultados

A total of 7 studies were included, comprising 4,797,161 patients; 2,448,045 (51%) were males and 2,349,116 (49%) were females. The results indicated a higher risk of cancer in people suffering from insomnia (HR 1.17; 95% CI 1.02-1.35; p = 0.03; I² = 92%). However, in the subgroup analysis with only Prospective Cohort, there was no statistical significance (HR 1.17; 95% CI 0.96-1.44; p = 0.13; I² = 77%). There were no significant statistical differences in the sex analyses: male (HR 1.26; 95% CI 0.96-1.65; p = 0.09; I² = 89%) and female (HR 1.15; 95% CI 1.00-1.31; p = 0.05; I² = 91%).

Conclusões

In this meta-analysis of 7 studies, insomnia is directly associated with the risk of developing cancer. Thus, practicing sleep hygiene is crucial for overall health and wellness, which entails implementing habits that support regular, restful and rejuvenating sleep.

Palavras -chave

Insomnia; Cancer; Risk of Cancer.