Dados do Trabalho

Título

ASSOCIATION BETWEEN OBSTRUCTIVE SLEEP APNEA AND CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS

Introdução

Obstructive sleep apnea (OSA) is characterized by a disorder that leads to obstruction of the airways during sleep, in addition to being related to other health problems including cancer. Studies suggest that recurrence of obstructive sleep apnea has been linked to oxidative stress and changes in hormone levels, which may increase the risk of developing cancer.

Objetivo

This study aims to test the association between obstructive sleep apnea and the risk of cancer.

Métodos

Embase, Cochrane, and PubMed databases were searched for studies that addressed the correlation of obstructive sleep apnea (OSA) with the risk of cancer. A Random-effects Model was employed to compute the Hazard Ratios (HR) with 95% Confidence Intervals (CI). Statistical Analyses were performed utilizing ReviewManager (RevMan) 5.4.1.

Resultados

A total of 11 studies were included, of which 1 was case-control and 10 were cohorts, comprising 11,145,255 patients. The meta-analysis results indicated a higher risk of thyroid cancer (HR 2.27; 95% CI 1.26-4.09; p = 0.007; I² = 97%), lung cancer (HR 1.28; 95% CI 1.04-1.57: p = 0.02; I² = 98%) and colorectal cancer (HR 1.68; 95% CI 1.38-2.04; p < 0.00001; I² = 44%) for patients who do not suffer from OSA. However, there were no significant results related to the risk of prostate cancer (HR 1.43; 95% CI 0.72-2.86; p = 0.31; I² = 100%), non-Hodgkin's lymphoma ( HR 1.15; 95% CI 0.68-1.92; p = 0.60; I² = 67%), breast cancer (HR 1.36; 95% CI 0.98-1.87; p = 0.06; I² = 96%) and the overall risk of cancer (HR 1.53; 95% CI 0.78- 3.02; p = 0.22; I² = 99%) when analyzing individuals who are affected or not with OSA.

Conclusões

In this meta-analysis of 11 studies, obstructive sleep apnea is not associated with overall cancer risk, however, some types did not have significant results to apply. Therefore, there is a need for more studies to investigate the occurrence of some types of cancer in patients with OSA.

Palavras -chave

Obstructive sleep apnea; Cancer risk; Thyroid cancer; Lung cancer; Colorectal cancer.